Preheat oven to 400ºF.
Bring a large pot of salted water to a boil on stovetop to cook your macaroni pasta to al dente according to package directions.
In a separate large pot, melt the six tablespoons of butter over medium heat. Add the all purpose flour and whisk to create a roux. Cook the roux for 2 minutes, whisking constantly. Add your spices and whisk them in as well.
Add milk and heavy cream, about ½ cup at a time, whisking well with each addition. After about two cups of liquid has been added, pour in the rest of the milk and heavy cream, add the sour cream, and whisk well to combine.
Cook for 5-7 minutes, whisking frequently so the bottom doesn't scorch. Once the white sauce is thick enough to coat the back of a spoon and stay separated when you run a finger down that spoon, it's ready for cheese.
Turn the sauce's temperature to low and add a handful of the cheese at a time, whisking in each handful before adding the next. Once the cheeses are fully incorporated, turn the heat off.
Once your pasta is al dente, drain it and stir the macaroni into the cheese sauce to really get the sauce into the pasta.
Toast the panko bread crumbs and 2 tablespoon butter together in a separate saute pan until it's lightly toasted for a minute over medium heat, set aside.
Butter your 9x13 baking dish (or equivalent sized baking dish) and pour the macaroni and cheese into it. Smooth the mac down with the back of a spoon then cover the top with the toasted panko.
Bake in the oven for 25-30 minutes, until the breadcrumbs are golden brown and the cheese is bubbling.
Cool for five minutes, then serve hot!